Most of the book comprises chapters that explain the major neuroanatomical systems. Each chapter first presents background material including an overview of relevant neuroanatomical structures and pathways, and a brief discussion of related clinical disorders. The second half of each chapter is devoted to clinical cases. The cases begin with a narrative of how the patient developed symptoms, and what deficits were found upon neurological examination. Boldface type highlights important symptoms and signs. A series of questions challenges the reader to deduce the neuroanatomical location of the patient's lesion, and the diagnosis. Discussion and answers follow, and an epilogue reveals the actual outcome.

One of the book's most innovative features is the inclusion of CT and MRI scans that depict each patient's lesion. These radiographs help the reader develop skills in interpreting the same kinds of diagnostic images employed in clinical practice.

The book is intended primarily for first- or second-year medical students enrolled in a basic neuroanatomy, neurobiology or neuroscience course. It is also a valuable resource for advanced medical students and residents, as well as students of other health professions, notably physical therapy, occupational therapy, nursing, dentistry, speech therapy, and neuropsychology.